(R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Base Information

Chemical Name:(R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
CAS No.:329926-53-6
Molecular Formula:C₁₈H₁₅ClF₄N₂O₃S
Molecular Weight:450.841
Hs Code.:

Synonyms:(R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Chemical Property of (R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Technology Process of (R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

There total 2 articles about (R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-acetamido-2-chloro-4-(4-fluorophenylsulphanyl)aniline

: 243982-40-3
(S)-3,3,3-trifluoro-2-methyl-2-trimethylsilanyloxy-propionyl chloride

: 329926-53-6
(R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: 3-acetamido-2-chloro-4-(4-fluorophenylsulphanyl)aniline; (S)-3,3,3-trifluoro-2-methyl-2-trimethylsilanyloxy-propionyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃;

With hydrogenchloride; In methanol; water;

Reference yield:

: 371-42-6
4-Fluorothiophenol

: 329926-53-6
(R)-N-(3-Acetamido-2-Chloro-4-{4-fluorophenylsulphanyl}phenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h

1.2: 3 h / -65 °C

2.1: iron(III) chloride; zinc / water / 1 h / 100 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

With iron(III) chloride; sodium hydride; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water;