1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

Base Information

Chemical Name:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone
CAS No.:181869-24-9
Molecular Formula:C₂₃H₂₂F₂N₈O₂
Molecular Weight:480.477
Hs Code.:

Synonyms:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

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Chemical Property of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

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Technology Process of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

There total 10 articles about 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 181869-23-8
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone

: 181869-24-9
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; at 20 ℃;
DOI:10.1248/cpb.48.1947

Reference yield:

: 181869-75-0
phenyl 4-(1H-1,2,3-triazol-1-yl)phenylcarbamate

: 181869-24-9
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / pyridine / 3 h / 50 °C

2.1: 86 percent / aq. HCl / methanol / 14 h / 20 °C

3.1: NaH / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

3.2: 38 percent / 1-methyl-pyrrolidin-2-one / 19 h / 80 °C

4.1: 86 percent / H₂; AcOH / 10 percent Pd/C / 6 h / 20 - 50 °C

With pyridine; hydrogenchloride; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1248/cpb.48.1935

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 181869-24-9
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 50 percent / K₂CO₃ / dimethylformamide / 70 - 80 °C

2.1: 96 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C

3.1: 97 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 95 percent / pyridine / 3 h / 50 °C

5.1: 86 percent / aq. HCl / methanol / 14 h / 20 °C

6.1: NaH / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

6.2: 38 percent / 1-methyl-pyrrolidin-2-one / 19 h / 80 °C

7.1: 86 percent / H₂; AcOH / 10 percent Pd/C / 6 h / 20 - 50 °C

With pyridine; hydrogenchloride; hydrogen; sodium hydride; potassium carbonate; acetic acid; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1935