ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate
• CAS No.: 1623023-29-9
• Molecular Formula: C₂₀H₂₀N₂O₂S
• Molecular Weight: 352.457
• Mol file: 1623023-29-9.mol

Synonyms:ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate

Chemical Property of ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate

There total 2 articles about ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 2-(2-methyl-4-oxo-5,6-dihydro-4H-cyclopenta[b]thiophen-5-yl)-2-oxoacetate (1623023-26-6) + 4-methylbenzylhydrazine (51421-17-1) → ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate (1623023-29-9)

Guidance literature:

With acetic acid; at 110 ℃; for 8h;

DOI:10.1016/j.ejmech.2014.08.042

Reference yield:

2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-4-one (67838-96-4) → ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate (1623023-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium; ethanol / 5 h / 20 °C

2: acetic acid / 8 h / 110 °C

With ethanol; sodium; acetic acid; 1: |Claisen Condensation;

DOI:10.1016/j.ejmech.2014.08.042

Reference yield: 90.0%

ethyl 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylate (1623023-29-9) → 6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylic acid (1623023-32-4)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 80 ℃; for 5h;

DOI:10.1016/j.ejmech.2014.08.042

upstream raw materials:

ethyl 2-(2-methyl-4-oxo-5,6-dihydro-4H-cyclopenta[b]thiophen-5-yl)-2-oxoacetate

4-methylbenzylhydrazine

2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-4-one

Downstream raw materials:

6-methyl-1-(4-methylbenzyl)-1,4-dihydrothieno[2',3'-4,5]cyclopenta[1,2c]pyrazole-3-carboxylic acid