4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester

Base Information

• Chemical Name: 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester
• CAS No.: 160064-57-3
• Molecular Formula: C₂₅H₃₀NO₃P
• Molecular Weight: 423.492
• Mol file: 160064-57-3.mol

Synonyms:4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester

Chemical Property of 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester

There total 3 articles about 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(N,N-di-p-tolylamino)benzyl alcohol (148077-49-0) + triethyl phosphite (122-52-1) → 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester (160064-57-3)

Guidance literature:

With iodine; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.7b13243

Reference yield:

4-[N,N-di(p-tolyl)amino]benzaldehyde (42906-19-4) → 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester (160064-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 4 h / Reflux

2: iodine / 12 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; iodine; In ethanol;

DOI:10.1021/jacs.7b13243

Reference yield:

4-chloromethyl-4',4-dimethyltriphenylamine + triethyl phosphite (122-52-1) → 4-[N,N-di(p-tolyl)amino]benzylphosphonic acid diethyl ester (160064-57-3)

Guidance literature:

upstream raw materials:

triethyl phosphite

4-(N,N-di-p-tolylamino)benzyl alcohol

4-[N,N-di(p-tolyl)amino]benzaldehyde