N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

Base Information

Chemical Name:N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide
CAS No.:885679-13-0
Molecular Formula:C₂₂H₂₃Cl₂FN₂O₄S
Molecular Weight:501.406
Hs Code.:

Synonyms:N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

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Chemical Property of N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

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Technology Process of N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

There total 4 articles about N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 885679-10-7
2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(2-chlorobenzyl)pent-4-enamide

: 6186-91-0
3-chloro-2-fluoropropene

: 885679-13-0
N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

Guidance literature:: 2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(2-chlorobenzyl)pent-4-enamide; With sodium hydride; In N,N-dimethyl-formamide; at 10 ℃; for 0.25h;

3-chloro-2-fluoropropene; In N,N-dimethyl-formamide; at 50 ℃; for 12h;
DOI:10.1002/ejoc.200500826

Reference yield:

: 885679-07-2
2-([(5-chloro-2-methoxyphenyl)sulfonyl]amino)pent-4-enoic acid

: 885679-13-0
N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; EDCI / CH₂Cl₂ / 1 h / 20 °C

1.2: 99 percent / CH₂Cl₂ / 12 h / 20 °C

2.1: NaH / dimethylformamide / 0.25 h / 10 °C

2.2: 30 percent / dimethylformamide / 12 h / 50 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200500826

Reference yield:

: 1069-48-3,7685-44-1
rac-allylglycine

: 885679-13-0
N-(2-chlorobenzyl)-2-[(5-chloro-2-methoxyphenylsulfonyl)(2-fluoroallyl)amino]-4-pentenamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Me₃SiCl / CH₂Cl₂ / 2 h / Heating

1.2: 80 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: HOBt; EDCI / CH₂Cl₂ / 1 h / 20 °C

2.2: 99 percent / CH₂Cl₂ / 12 h / 20 °C

3.1: NaH / dimethylformamide / 0.25 h / 10 °C

3.2: 30 percent / dimethylformamide / 12 h / 50 °C

With chloro-trimethyl-silane; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200500826