(-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

Base Information

Chemical Name:(-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane
CAS No.:96843-45-7
Molecular Formula:C₂₄H₄₀O₃S
Molecular Weight:408.646
Hs Code.:

Synonyms:(-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

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Chemical Property of (-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

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Technology Process of (-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

There total 14 articles about (-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96843-37-7,96894-96-1
C₂₅H₃₆O₄S

: 96843-45-7
(-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / HCl, H₂ / 5percent Pd/C / methanol / 5 h / Ambient temperature

2: 98 percent / p-toluenesulfonic acid / 10 h / Heating

3: 1.) O₃, 2.) LiOH / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) THF, RT, 2 h

4: 73 percent / camphorsulfonic acid / benzene / 2 h / Heating

5: 72 percent / LiAlH₄ / tetrahydrofuran / 9 h / Ambient temperature

6: 93 percent / 4-(dimethylamino)pyridine, pyridine / 5 h / Ambient temperature

7: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

8: 95 percent / HCl / acetone / 6 h / Ambient temperature

9: 2.) NaH / 1.) ether, RT, 1 h, 2.) THF, reflux, 12 h

10: 1.) BH₃*SMe₂, 2.) aq. NaOH, H₂O₂ / 1.) 0 deg C - RT, 1.5 h, 2.) a) ) deg C, 30 min, b) 50 deg C, 1 h

With pyridine; hydrogenchloride; dmap; lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; dimethylsulfide borane complex; camphor-10-sulfonic acid; hydrogen; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; ozone; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1021/jo00376a049

Reference yield:

: 105764-33-8
(R)-2-[(1R,2R,3R)-3-Benzenesulfonylmethyl-2-methyl-2-(2-oxo-ethyl)-cyclopentyl]-6-methyl-heptanoic acid

: 96843-45-7
(-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / camphorsulfonic acid / benzene / 2 h / Heating

2: 72 percent / LiAlH₄ / tetrahydrofuran / 9 h / Ambient temperature

3: 93 percent / 4-(dimethylamino)pyridine, pyridine / 5 h / Ambient temperature

4: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

5: 95 percent / HCl / acetone / 6 h / Ambient temperature

6: 2.) NaH / 1.) ether, RT, 1 h, 2.) THF, reflux, 12 h

7: 1.) BH₃*SMe₂, 2.) aq. NaOH, H₂O₂ / 1.) 0 deg C - RT, 1.5 h, 2.) a) ) deg C, 30 min, b) 50 deg C, 1 h

With pyridine; hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; dimethylsulfide borane complex; camphor-10-sulfonic acid; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; acetone; benzene;
DOI:10.1021/jo00376a049

Reference yield:

: 96843-39-9
(-)-(1S,3aR,4R,7aS)-5-acetoxy-1-<(phenylsulfonyl)methyl>-4-(4-methylpentyl)-3a,4,7,7a-tetrahydro-7a-methylindan

: 96843-45-7
(-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-<(phenylsulfonyl)methyl>-3(R)-(1(R),5-dimethylhexyl)cyclopentane

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) O₃, 2.) LiOH / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) THF, RT, 2 h

2: 73 percent / camphorsulfonic acid / benzene / 2 h / Heating

3: 72 percent / LiAlH₄ / tetrahydrofuran / 9 h / Ambient temperature

4: 93 percent / 4-(dimethylamino)pyridine, pyridine / 5 h / Ambient temperature

5: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

6: 95 percent / HCl / acetone / 6 h / Ambient temperature

7: 2.) NaH / 1.) ether, RT, 1 h, 2.) THF, reflux, 12 h

8: 1.) BH₃*SMe₂, 2.) aq. NaOH, H₂O₂ / 1.) 0 deg C - RT, 1.5 h, 2.) a) ) deg C, 30 min, b) 50 deg C, 1 h

With pyridine; hydrogenchloride; dmap; lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; dimethylsulfide borane complex; camphor-10-sulfonic acid; dihydrogen peroxide; sodium hydride; ozone; In tetrahydrofuran; acetone; benzene;
DOI:10.1021/jo00376a049