1-(Pyrrolidin-2-ylmethyl)pyrrolidine

Base Information

Chemical Name:1-(Pyrrolidin-2-ylmethyl)pyrrolidine
CAS No.:60419-23-0
Molecular Formula:C9H18N2
Molecular Weight:154.255
Hs Code.:2933998090
European Community (EC) Number:837-948-7
NSC Number:116549
DSSTox Substance ID:DTXSID90965477
Nikkaji Number:J1.379.706D,J578.949D
Mol file:60419-23-0.mol

Synonyms:1-(pyrrolidin-2-ylmethyl)pyrrolidine;195311-28-5;1-(2-Pyrrolidinylmethyl)pyrrolidine;1-(2-Pyrrolidinylmethyl)pyrrolidine #;NSC116549;1,2'-methylenedipyrrolidine;SCHEMBL255277;DTXSID90965477;CHEBI:189194;2-(1-pyrrolidinyl)methylpyrrolidine;60419-23-0 (non-salt);BCP27164;VHA31128;MFCD06653330;1-(2-pyrrolidinylmethyl)-pyrrolidine;2-(1-pyrrolidinylmethyl) pyrrolidine;AKOS000257278;AKOS022180365;NSC-116549;1-[(Pyrrolidin-2-yl)methyl]pyrrolidine;2-[(pyrrolidin-1-yl)methyl]pyrrolidine;Pyrrolidine, 2.alpha.-[1-pyrrolidyl]-;AS-47749;SY024057;FT-0639974;FT-0658653;FT-0737980;EN300-56451;(S)-2-(1-Pyrrolidinylmethyl)pyrrolidine 2HCl;F16017;(R)-1-(2-Pyrrolidinylmethyl)pyrrolidine dihydrochloride;Z335286592

Suppliers and Price of 1-(Pyrrolidin-2-ylmethyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine
10mg
$ 45.00

TRC
(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine
50mg
$ 60.00

TCI Chemical
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine >98.0%(GC)(T)
1g
$ 162.00

SynQuest Laboratories
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 95%
5 g
$ 656.00

SynQuest Laboratories
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 95%
1 g
$ 192.00

Matrix Scientific
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 95+%
1g
$ 347.00

Matrix Scientific
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 95+%
10g
$ 1428.00

Matrix Scientific
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 95+%
5g
$ 998.00

Crysdot
(R)-1-(Pyrrolidin-2-ylmethyl)pyrrolidine 97%
5g
$ 495.00

Crysdot
(R)-1-(Pyrrolidin-2-ylmethyl)pyrrolidine 97%
1g
$ 139.00

Total 50 raw suppliers

Chemical Property of 1-(Pyrrolidin-2-ylmethyl)pyrrolidine

Chemical Property:

Vapor Pressure:0.00898mmHg at 25°C
Refractive Index:1.4850 to 1.4890
Boiling Point:265.8 °C at 760 mmHg
PKA:10.91±0.10(Predicted)
Flash Point:87.8 °C
PSA：15.27000
Density:0.975 g/cm³
LogP:1.10090
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:154.146998583
Heavy Atom Count:11
Complexity:119

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)CC2CCCN2

Technology Process of 1-(Pyrrolidin-2-ylmethyl)pyrrolidine

There total 15 articles about 1-(Pyrrolidin-2-ylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 144243-45-8,202990-49-6
(R)-(+)-1-prolinamidopyrrolidine

: 60419-23-0
(R)-(-)-1-(2-pyrrolidinylmethyl)pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm00101a011

Reference yield: 56.0%

: 144243-44-7,155251-70-0
tert-butyl (S)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

: 60419-23-0
(R)-(-)-1-(2-pyrrolidinylmethyl)pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 17h; Heating;
DOI:10.1081/SCC-100103998

Reference yield:

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 60419-23-0
(R)-(-)-1-(2-pyrrolidinylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole (HOBT) / CH₂Cl₂ / Ambient temperature

2: 100 percent / TFA / CH₂Cl₂ / 0.83 h / Ambient temperature

3: 91 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00101a011