Technology Process of 6-methyl-8-(p-tolylethynyl)-2,3-dihydroquinolin-4(1H)-one
There total 4 articles about 6-methyl-8-(p-tolylethynyl)-2,3-dihydroquinolin-4(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
8-iodo-6-methyl-2,3-dihydroquinolin-4(1H)-one;
With
copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine;
In
ethanol;
at 25 ℃;
for 1h;
Inert atmosphere;
4-n-methylphenylacetylene;
In
ethanol;
at 80 ℃;
for 2h;
Inert atmosphere;
DOI:10.1039/c0ob00771d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanesulfonic acid; phosphorus pentoxide / 12 h / 90 °C
2.1: Iodine monochloride; calcium carbonate / methanol; water / 2 h / 0 - 20 °C
3.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere
3.2: 2 h / 80 °C / Inert atmosphere
With
copper(l) iodide; methanesulfonic acid; phosphorus pentoxide; palladium 10% on activated carbon; Iodine monochloride; triethylamine; triphenylphosphine; calcium carbonate;
In
methanol; ethanol; water;
3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid / 4 h / 70 °C
2.1: methanesulfonic acid; phosphorus pentoxide / 12 h / 90 °C
3.1: Iodine monochloride; calcium carbonate / methanol; water / 2 h / 0 - 20 °C
4.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere
4.2: 2 h / 80 °C / Inert atmosphere
With
copper(l) iodide; methanesulfonic acid; phosphorus pentoxide; palladium 10% on activated carbon; Iodine monochloride; acetic acid; triethylamine; triphenylphosphine; calcium carbonate;
In
methanol; ethanol; water;
4.1: Sonogashira coupling / 4.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d
