2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

Base Information

Chemical Name:2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile
CAS No.:1449515-03-0
Molecular Formula:C₁₈H₁₇N₅O
Molecular Weight:319.366
Hs Code.:

Synonyms:2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

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Chemical Property of 2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

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Technology Process of 2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

There total 5 articles about 2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449515-03-0
2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 20 °C

2: iron; acetic acid / 50 - 80 °C

3: orthoformic acid triethyl ester / 4 h / 100 °C

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 18 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; orthoformic acid triethyl ester; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1449515-99-4
2-ethyl-4-isoxazol-4-ylphenylamine

: 7205-46-1
6-chloro-1-methyl-1H-imidazo[4,5-c]pyridine

: 1449515-03-0
2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

Reference yield:

: 45762-41-2
4-bromo-2-ethylaniline

: 1449515-03-0
2-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]-3-oxopropionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1.5 h / 20 °C / Inert atmosphere

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 18 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In water; N,N-dimethyl-formamide;