ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate

Base Information

• Chemical Name: ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate
• CAS No.: 437768-90-6
• Molecular Formula: C₂₉H₂₉N₃O₆
• Molecular Weight: 515.566
• Mol file: 437768-90-6.mol

Synonyms:ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate

Chemical Property of ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate

There total 4 articles about ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2-aminobenzoylamino)acetic acid ethyl ester (5973-34-2) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) → ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate (437768-90-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1021/ol030070l

Reference yield: 86.0%

(2-aminobenzoylamino)acetic acid ethyl ester (5973-34-2) + 9H-fluoren-9-ylmethyl [(1S)-2-chloro-1-methyl-oxoethyl]carbamate (103321-50-2) → ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate (437768-90-6)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0957-4166(02)00027-7

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → ethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-2-aminobenzoylglycinate (437768-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / EDCI / CH₂Cl₂ / 3 h / 20 °C

2: 89 percent / EDCI / acetonitrile / 5 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;

DOI:10.1021/ol030070l

upstream raw materials:

(2-aminobenzoylamino)acetic acid ethyl ester

9H-fluoren-9-ylmethyl [(1S)-2-chloro-1-methyl-oxoethyl]carbamate

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

anthranilic acid