p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

Base Information

Chemical Name:p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate
CAS No.:127132-84-7
Molecular Formula:C₂₆H₂₅N₃O₉
Molecular Weight:523.499
Hs Code.:

Synonyms:p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

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Chemical Property of p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

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Technology Process of p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

There total 4 articles about p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (6R,7S)-3-Hydroxymethyl-8-oxo-7-(2-phenoxy-acetylamino)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 108-24-7
acetic anhydride

: 127132-84-7
p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 ℃; for 18h; Yield given;
DOI:10.1021/jm00168a019

Reference yield:

: 127023-91-0
p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-vinyl-1-carba-1-dethia-3-cephem-4-carboxylate

: 127132-84-7
p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / O₃ / CH₂Cl₂; methanol / 0.67 h / -78 °C

2: lithium tri(tert-butoxy)aluminum hydride / tetrahydrofuran / 1 h / -35 °C

3: pyridine / tetrahydrofuran / 18 h / 0 °C

With pyridine; ozone; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00168a019

Reference yield:

: 127132-83-6
p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-formyl-1-carba-1-dethia-3-cephem-4-carboxylate

: 127132-84-7
p-nitrobenzyl (7S,6R)-7-(phenoxyacetamido)-3-(acetoxymethyl)-1-carba-1-dethia-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium tri(tert-butoxy)aluminum hydride / tetrahydrofuran / 1 h / -35 °C

2: pyridine / tetrahydrofuran / 18 h / 0 °C

With pyridine; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran;
DOI:10.1021/jm00168a019