(2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Base Information

Chemical Name:(2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide
CAS No.:1287285-53-3
Molecular Formula:C₂₃H₃₁NO₃
Molecular Weight:369.504
Hs Code.:

Synonyms:(2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Suppliers and Price of (2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Chemical Property:

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Technology Process of (2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

There total 6 articles about (2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 7782-24-3
(S)-2-Phenylpropionic acid

: 1286280-73-6
(2R)-2-amino-2-[4-(2-methylpentyloxy)phenyl]ethanol hydrochloride

: 1287285-53-3
(2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.11.058

Reference yield:

: 7782-24-3
(S)-2-Phenylpropionic acid

: 1287285-53-3
(2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium methylate; methanol / 0.33 h / 0 - 20 °C

With methanol; sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran;

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 1287285-53-3
(2S)-N-{(1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 - 35 °C / Inert atmosphere

3: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 3 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium chloride; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2016.11.058