3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide

Base Information

• Chemical Name: 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide
• CAS No.: 144605-19-6
• Molecular Formula: C₁₆H₁₃ClN₂O₂S
• Molecular Weight: 332.81

Synonyms:3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide

Chemical Property of 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide

Chemical Property:

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Technology Process of 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide

There total 3 articles about 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-Chloro-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (144604-97-7) → 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide (144605-19-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; at 60 ℃; for 1h;

DOI:10.1002/ardp.19923250915

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide (144605-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / methanol / 2 h / Heating

2: 75 percent / NaBH₄ / ethanol; H₂O / 1 h / 60 °C

With sodium tetrahydroborate; In methanol; ethanol; water;

DOI:10.1002/ardp.19923250915

Reference yield:

3-chloro-2-hydrazinocarbonylbenzothiophene (62524-21-4) → 3-Chloro-benzo[b]thiophene-2-carboxylic acid N'-(4-hydroxy-benzyl)-hydrazide (144605-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / methanol / 2 h / Heating

2: 75 percent / NaBH₄ / ethanol; H₂O / 1 h / 60 °C

With sodium tetrahydroborate; In methanol; ethanol; water;

DOI:10.1002/ardp.19923250915

upstream raw materials:

3-Chloro-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

4-hydroxy-benzaldehyde

3-chloro-2-hydrazinocarbonylbenzothiophene

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