2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

Base Information

Chemical Name:2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole
CAS No.:1081111-70-7
Molecular Formula:C₃₄H₃₂Cl₂N₄O
Molecular Weight:583.56
Hs Code.:

Synonyms:2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

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Technology Process of 2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

There total 9 articles about 2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1081112-56-2
2-(4-chlorophenyl)-1-{3-[4-(3-aminophenyl)piperidin-1-yl]propyl}-1H-benzimidazole

: 618-46-2
m-Chlorobenzoyl chloride

: 1081111-70-7
2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.02.099

Reference yield: 92.0%

: 1081111-70-7
2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

Guidance literature:

Reference yield:

N₁-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride: 486430-92-6
N₁-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride

: 1081111-70-7
2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamino)phenyl)piperidin-1-yl]propyl}-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

2: triethylamine / dichloromethane / 3 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

4: hydrogenchloride / methanol; water / 3 h / 50 °C

5: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.02.099