N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide
CAS No.:1616385-64-8
Molecular Formula:C₂₀H₁₅ClF₃N₅O₂
Molecular Weight:449.82
Hs Code.:

Synonyms:N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

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Technology Process of N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

There total 3 articles about N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1022922-16-2
[2-chloro-5-(trifluoromethoxy)phenyl]boronic acid

: 1616387-37-1
N-(2-iodo-1H-pyrrolo[2,3-b]pyridin-5-yl)-3,4-dimethyl-1H-pyrazole-5-carboxamide

: 1616385-64-8
N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: With dichloro(1,1-bis(diphenylphosphino)ferrocene)palladium(II) acetone adduct; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1616461-24-5
2-iodo-1H-pyrrolo[2,3-b]pyridin-5-amine

: 1616385-64-8
N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl acetamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: dichloro(1,1-bis(diphenylphosphino)ferrocene)palladium(II) acetone adduct; potassium carbonate / 1,4-dioxane; water / 0.33 h / 120 °C / Microwave irradiation

With dichloro(1,1-bis(diphenylphosphino)ferrocene)palladium(II) acetone adduct; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water;

Reference yield:

: 89831-40-3
3,4-dimethyl-2H-pyrazole-5-carboxylic acid

: 1616385-64-8
N-[2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl acetamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: dichloro(1,1-bis(diphenylphosphino)ferrocene)palladium(II) acetone adduct; potassium carbonate / 1,4-dioxane; water / 0.33 h / 120 °C / Microwave irradiation

With dichloro(1,1-bis(diphenylphosphino)ferrocene)palladium(II) acetone adduct; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water;