(S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

Base Information

Chemical Name:(S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide
CAS No.:101460-53-1
Molecular Formula:C₁₈H₂₅BrN₂O₄
Molecular Weight:413.311
Hs Code.:

Synonyms:(S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

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Technology Process of (S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

There total 6 articles about (S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 125198-32-5
(S)-3-bromo-N-(2-pyrrolidinylmethyl)-2,5,6-trimethoxybenzamide

: 106-95-6
allyl bromide

: 101460-53-1
(S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1021/jm00166a012

Reference yield:

(S)-(+)-3-bromo-N-2-pyrrolidinylmethyl)-2,5,6-trimethoxybenzamide: (S)-(+)-3-bromo-N-2-pyrrolidinylmethyl)-2,5,6-trimethoxybenzamide

: 3-Bromo-2,5,6-trimethoxybenzamide chloride

: 125198-32-5
(S)-3-bromo-N-(2-pyrrolidinylmethyl)-2,5,6-trimethoxybenzamide

: 98598-84-6
S(+)-2-aminomethyl-1-triphenylmethylpyrrolidine

: 101460-53-1
(S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

: 55-21-0,27208-38-4
benzamide

Guidance literature:: With hydrogenchloride; sodium hydroxide; potassium carbonate; In dimethylformamide, allylbromide; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 135-77-3
1,2,4-trimethoxy-benzene

: 101460-53-1
(S)-N-<(1-allyl-2-pyrrolidinyl)methyl>-3-bromo-2,5,6-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, 20 deg C, 2.) Et₂O

2: Br₂ / dioxane / 1 h / Ambient temperature

3: thionyl chloride, DMF / toluene / 1 h / 60 °C

4: 2.) conc. aq. HCl / 1.) CH₂Cl₂, room temp., 1 h, 2.) EtOH, 1 h

5: 40 percent / K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

With hydrogenchloride; n-butyllithium; thionyl chloride; bromine; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00166a012