(S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate
CAS No.:1190707-65-3
Molecular Formula:C₃₀H₃₂Cl₃N₅O₃
Molecular Weight:616.975
Hs Code.:

Synonyms:(S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

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Technology Process of (S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

There total 8 articles about (S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2420-16-8
4-hydroxy-3-chlorobenzaldehyde

: 1190707-64-2
(S)-tert-butyl 3-((2-amino-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

: 1190707-65-3
(S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In N,N-dimethyl-formamide; at 20 - 100 ℃; pH=5;

Reference yield:

: 87-65-0
2,6-Dichlorophenol

: 1190707-65-3
(S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C

3: potassium tert-butylate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 50 °C

4: 2 h / 140 °C / Microwave irradiation

5: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C

6: sodium tris(acetoxy)borohydride; trifluoroacetic acid / N,N-dimethyl-formamide / 20 - 100 °C / pH 5

With pyridine; potassium tert-butylate; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 133280-47-4
2,6-dichlorophenyl trifluoromethanesulphonate

: 1190707-65-3
(S)-tert-butyl 3-((2-(3-chloro-4-hydroxybenzylamino)-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C

2: potassium tert-butylate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 50 °C

3: 2 h / 140 °C / Microwave irradiation

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C

5: sodium tris(acetoxy)borohydride; trifluoroacetic acid / N,N-dimethyl-formamide / 20 - 100 °C / pH 5

With potassium tert-butylate; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;