(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

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Chemical Name:(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid
CAS No.:1447711-29-6
Molecular Formula:C₂₉H₄₀N₂O₇
Molecular Weight:528.646
Hs Code.:

Synonyms:(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

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Chemical Property of (S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

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Technology Process of (S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

There total 11 articles about (S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1447711-26-3
(S)-dimethyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinate

: 1447711-29-6
(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

Guidance literature:: With lithium hydroxide dihydrate; water; In tetrahydrofuran; at 25 ℃;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 499-76-3
4-hydroxy-3-methylbenzoic acid

: 1447711-29-6
(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: potassium carbonate; potassium iodide / 6 h / Reflux

3.1: diethyl ether / 2 h / 0 - 30 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 2 h / 25 °C

6.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

7.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

8.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

10.1: water; lithium hydroxide dihydrate / tetrahydrofuran / 25 °C

With lithium hydroxide dihydrate; sulfuric acid; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 1447711-29-6
(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-ethylpyrrole-2-carboxamido)succinic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 25 °C

3.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

4.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

5.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

7.1: water; lithium hydroxide dihydrate / tetrahydrofuran / 25 °C

With lithium hydroxide dihydrate; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015