13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

Base Information

Chemical Name:13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid
CAS No.:1427550-05-7
Molecular Formula:C₂₀H₂₁N₃O₃
Molecular Weight:351.405
Hs Code.:

Synonyms:13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

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Chemical Property of 13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

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Technology Process of 13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

There total 6 articles about 13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1427550-04-6
methyl 13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate

: 1427550-05-7
13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

Guidance literature:: With water; potassium hydroxide; In 1,4-dioxane; for 0.25h; Reflux;

Reference yield:

: 1427550-02-4
1-[2-(2-chloroethoxy)phenyl]-2-cyclohexylethanone

: 1427550-05-7
13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / 1,4-dioxane; diethyl ether / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

2.2: 22 h / 20 - 100 °C

3.1: water; potassium hydroxide / 1,4-dioxane / 0.25 h / Reflux

With water; bromine; sodium hydride; potassium hydroxide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1427550-01-3
1-[2-(2-chloroethoxy)phenyl]-2-(1-hydroxycyclohexyl)ethanone

: 1427550-05-7
13-cyclohexyl-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 60 h / 20 °C / Inert atmosphere

2.1: bromine / 1,4-dioxane; diethyl ether / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

3.2: 22 h / 20 - 100 °C

4.1: water; potassium hydroxide / 1,4-dioxane / 0.25 h / Reflux

With triethylsilane; water; bromine; sodium hydride; trifluoroacetic acid; potassium hydroxide; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;