(2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate
• CAS No.: 1434302-12-1
• Molecular Formula: C₃₃H₂₉NO₄
• Molecular Weight: 503.598
• Mol file: 1434302-12-1.mol

Synonyms:(2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate

Chemical Property of (2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate

There total 1 articles about (2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-bromonaphthalene (580-13-2) + 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane (80986-14-7) → (2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate (1434302-12-1)

Guidance literature:

2-bromonaphthalene; With magnesium; In tetrahydrofuran; for 0.75h; Inert atmosphere; Reflux;

5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.201200922

Reference yield: 74.0%

(2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate (1434302-12-1) + dimethylsilicon dichloride (75-78-5,30107-43-8) → (1S,6S)-benzyl 3,3-dimethyl-5,5-di(naphthalen-2-yl)-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate (1434302-16-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 21h; Inert atmosphere;

DOI:10.1002/adsc.201200922

upstream raw materials:

2-bromonaphthalene

5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane

Downstream raw materials:

(1S,6S)-benzyl 3,3-dimethyl-5,5-di(naphthalen-2-yl)-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate