1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 81625-17-4
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 81625-17-4.mol

Synonyms:1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<4-(benzyloxy)benzyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (81625-19-6) → 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline (81625-17-4,5843-63-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; for 18h; under 2585.7 Torr;

DOI:10.1021/jo00134a025

Reference yield:

3,4-dihydro-6-methoxy-1-<4-(benzyloxy)benzyl>isoquinoline (76786-97-5) → 4-(6-Methoxy-isoquinolin-1-ylmethyl)-phenol (81625-28-7) + 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline (81625-17-4,5843-63-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 12h; under 2585.7 Torr; Title compound not separated from byproducts;

DOI:10.1021/jo00134a025

Reference yield:

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) → 1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline (81625-17-4,5843-63-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / xylene / 24 h / Heating

2: 75 percent / POCl₃ / toluene / 1.5 h / 87 °C

3: H₂, concd HCl / 10percent Pd/C / ethanol / 12 h / 2585.7 Torr

With hydrogenchloride; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol; toluene; xylene;

DOI:10.1021/jo00134a025

upstream raw materials:

1-<4-<(cyclohexylmethyl)oxy>benzyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

1-<4-(benzyloxy)benzyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

3,4-dihydro-6-methoxy-1-<4-(benzyloxy)benzyl>isoquinoline

2-[4-(benzyloxy)benzyl]acetic acid