Technology Process of 4-azido-2,3-di-O-benzyl-4,6-dideoxy-β-D-glucopyranosyl trichloroacetimidate
There total 11 articles about 4-azido-2,3-di-O-benzyl-4,6-dideoxy-β-D-glucopyranosyl trichloroacetimidate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 26.9 g / camphorsulfonic acid / acetonitrile / 5 h / pH 3
2.1: 60 percent sodium hydride / dimethylformamide / 0.25 h / 0 °C
2.2: 89 percent / dimethylformamide / 5 h
3.1: 93 percent / AcOH; water / 18 h / 50 °C
4.1: 84 percent / pyridine / 96 h / 20 °C
5.1: 83 percent / LiAlH4 / tetrahydrofuran / 18 h / -10 °C / Heating
6.1: 78 percent / pyridine; DMAP / 18 h / 50 °C
7.1: 80 percent / NaN3 / dimethylformamide / 72 h / 70 °C
8.1: TFA / CH2Cl2; diethyl ether / 3 h
9.1: 74 percent / K2CO3 / CH2Cl2 / 12 h
With
pyridine; dmap; lithium aluminium tetrahydride; sodium azide; camphor-10-sulfonic acid; water; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0008-6215(01)00323-8
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: NaOCH3 / methanol / 18 h
2.1: 26.9 g / camphorsulfonic acid / acetonitrile / 5 h / pH 3
3.1: 60 percent sodium hydride / dimethylformamide / 0.25 h / 0 °C
3.2: 89 percent / dimethylformamide / 5 h
4.1: 93 percent / AcOH; water / 18 h / 50 °C
5.1: 84 percent / pyridine / 96 h / 20 °C
6.1: 83 percent / LiAlH4 / tetrahydrofuran / 18 h / -10 °C / Heating
7.1: 78 percent / pyridine; DMAP / 18 h / 50 °C
8.1: 80 percent / NaN3 / dimethylformamide / 72 h / 70 °C
9.1: TFA / CH2Cl2; diethyl ether / 3 h
10.1: 74 percent / K2CO3 / CH2Cl2 / 12 h
With
pyridine; dmap; lithium aluminium tetrahydride; sodium azide; camphor-10-sulfonic acid; water; sodium methylate; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0008-6215(01)00323-8
