5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one

Base Information

• Chemical Name: 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one
• CAS No.: 136308-36-6
• Molecular Formula: C₂₀H₂₀O₅
• Molecular Weight: 340.376
• Mol file: 136308-36-6.mol

Synonyms:5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one

Chemical Property of 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one

There total 4 articles about 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-Hydroxy-5-((E)-propenyl)-2-(2,4,6-trimethoxy-phenyl)-2,3-dihydro-benzofuran-2-carboxylic acid allyl ester → 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one (136308-36-6)

Guidance literature:

With formic acid; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1016/S0040-4039(00)79388-9

Reference yield:

5-(E)-propenyl-3(2H)-benzofuranone (136308-33-3) → 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one (136308-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA / THF, -78 deg C

2: 85 percent / pyridine / CHCl₃ / 5 h / 60 °C

3: 81 percent / PPh₃, HCOOH, NEt₃ / Pd(OAc)2 / tetrahydrofuran / 72 h / Ambient temperature

With pyridine; formic acid; triethylamine; triphenylphosphine; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; chloroform;

DOI:10.1016/S0040-4039(00)79388-9

Reference yield:

3-Hydroxy-5-((E)-propenyl)-benzofuran-2-carboxylic acid allyl ester (136308-34-4) → 5-((E)-Propenyl)-2-(2,4,6-trimethoxy-phenyl)-benzofuran-3-one (136308-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine / CHCl₃ / 5 h / 60 °C

2: 81 percent / PPh₃, HCOOH, NEt₃ / Pd(OAc)2 / tetrahydrofuran / 72 h / Ambient temperature

With pyridine; formic acid; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; chloroform;

DOI:10.1016/S0040-4039(00)79388-9

upstream raw materials:

5-(E)-propenyl-3(2H)-benzofuranone

3-Hydroxy-5-((E)-propenyl)-benzofuran-2-carboxylic acid allyl ester

E-1-(4'-methoxyphenyl)prop-1-ene

Downstream raw materials:

5-(E)-propenyl-2(2,4,6-trimethoxyphenyl)-3(2H)-benzofuran