(E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide

Base Information

• Chemical Name: (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide
• CAS No.: 800394-17-6
• Molecular Formula: C₂₃H₂₂N₂O₄
• Molecular Weight: 390.439
• Mol file: 800394-17-6.mol

Synonyms:(E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide

Chemical Property of (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide

There total 5 articles about (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(Z)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide (800393-94-6) → 3,4-dihydro-1-methyl-3-(2,4-dimethoxybenzoylamino)-2(1H)-benzo[f]quinolinone + (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide (800394-17-6)

Guidance literature:

With TEA; In methanol; at 20 ℃; for 6h; Irradiation;

DOI:10.1016/j.tet.2004.08.096

Reference yield: 6.0%

(Z)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide (800393-94-6) → 3-(4-anisoylamino)-3,4-dihydro-1-methyl-2(1H)-benzo[f]quinolinone + (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide (800394-17-6)

Guidance literature:

With TEA; In methanol; at 20 ℃; for 0.5h; Irradiation;

DOI:10.1016/j.tet.2004.08.096

Reference yield:

2.6-Dimethoxy-hippursaeure → (E)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide (800394-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1: AcONa; Ac₂O / 65 - 75 °C

2: CHCl₃ / 20 °C

3: 6 percent / TEA / methanol / 0.5 h / 20 °C / Irradiation

With TEA; sodium acetate; acetic anhydride; In methanol; chloroform;

DOI:10.1016/j.tet.2004.08.096

upstream raw materials:

(Z)-2-(2,4-dimethoxybenzoylamino)-N-methyl-3-(1-naphthyl)-2-propenamide

1-naphthaldehyde

(Z)-2-(2,4-dimethoxyphenyl)-4-(1-naphthylmethylene)-5(4H)-oxazolone