(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

Base Information

Chemical Name:(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone
CAS No.:130675-41-1
Molecular Formula:C₁₆H₂₁NO₅
Molecular Weight:307.346
Hs Code.:

Synonyms:(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

Chemical Property:

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Technology Process of (5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

There total 1 articles about (5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 94615-12-0
(S)-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 5437-45-6
Benzyl bromoacetate

: 130675-41-1
(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1248/cpb.38.1601

Reference yield:

: 130675-41-1
(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

: 94615-19-7
(3R,4S)-3-(pyrrolidin-2,5-dion-1-yl)-2-azetidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / H₂ / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature

2: 63 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 20 h / 0 °C

3: 85 percent / 10percent aq. HCl / methanol / 2 h / 55 °C

4: 89 percent / Jones reagent / acetone / 2 h / Ambient temperature

5: 0.8 g / K₂CO₃ / dimethylformamide / 2.5 h / 50 °C

6: 590 mg / acetic acid; H₂O; ethyl acetate / 3 h / 50 °C

7: 83 percent / Jones reagent / acetone / 1.5 h / Ambient temperature

With hydrogenchloride; jones reagent; TEA; hydrogen; potassium carbonate; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.38.1601

Reference yield:

: 130675-41-1
(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

: 130675-43-3
Acetic acid 5-oxo-1-((3R,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-pyrrolidin-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / H₂ / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature

2: 63 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 20 h / 0 °C

3: 85 percent / 10percent aq. HCl / methanol / 2 h / 55 °C

4: 89 percent / Jones reagent / acetone / 2 h / Ambient temperature

5: 0.8 g / K₂CO₃ / dimethylformamide / 2.5 h / 50 °C

With hydrogenchloride; jones reagent; TEA; hydrogen; potassium carbonate; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.38.1601