1-[(2-Aminophenyl)methyl]pyrrole-2-carboxamide

Base Information

Chemical Name:1-[(2-Aminophenyl)methyl]pyrrole-2-carboxamide
CAS No.:27046-49-7
Molecular Formula:C₁₂H₁₃N₃O
Molecular Weight:215.255
Hs Code.:
DSSTox Substance ID:DTXSID001226217

Synonyms:27046-49-7;DTXSID001226217;1-[(2-Aminophenyl)methyl]-1H-pyrrole-2-carboxamide

Suppliers and Price of 1-[(2-Aminophenyl)methyl]pyrrole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(2-Aminophenyl)methyl]pyrrole-2-carboxamide

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:215.105862047
Heavy Atom Count:16
Complexity:257

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CN2C=CC=C2C(=O)N)N

Technology Process of 1-[(2-Aminophenyl)methyl]pyrrole-2-carboxamide

There total 2 articles about 1-[(2-Aminophenyl)methyl]pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 27046-47-5
1-(2-nitrobenzyl)-2-pyrrolecarbonitrile

: 27046-49-7
1-(2-aminobenzyl)-2-pyrrolecarboxamide

Guidance literature:: With sodium hydroxide; In ethylene glycol; at 100 ℃; for 5h;
DOI:10.1021/jm00178a020

Reference yield:

: 22162-52-3
1-(2-nitrobenzyl)-2-pyrrolecarboxaldehyde oxime

: 27046-49-7
1-(2-aminobenzyl)-2-pyrrolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Ac₂O / 2 h / 140 °C

2: 49 percent / aq. NaOH / ethane-1,2-diol / 5 h / 100 °C

With sodium hydroxide; acetic anhydride; In ethylene glycol;
DOI:10.1021/jm00178a020