2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile

Base Information

• Chemical Name: 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile
• CAS No.: 1443221-68-8
• Molecular Formula: C₃₂H₂₁F₂N₅O₂
• Molecular Weight: 545.548
• Mol file: 1443221-68-8.mol

Synonyms:2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile

Chemical Property of 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile

There total 5 articles about 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C17H10N2O2 (1038727-72-8) + C12H11F2NO (1443221-92-8) + malononitrile (109-77-3) → 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile (1443221-68-8)

Guidance literature:

With piperidine; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.03.017

Reference yield:

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile (1443221-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2: piperidine / ethanol / Reflux

With piperidine; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.03.017

Reference yield:

1,3-cylohexanedione (504-02-9) → 2'-amino-2-(4-cyanophenoxy)-1'-(3,4-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'carbonitrile (1443221-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / Reflux

2: piperidine / ethanol / Reflux

With piperidine; acetic acid; In methanol; ethanol;

DOI:10.1016/j.ejmech.2013.03.017

upstream raw materials:

C₁₇H₁₀N₂O₂

C₁₂H₁₁F₂NO

malononitrile

2-chloro-3-quinoline carboxaldehyde