(3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Base Information

• Chemical Name: (3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one
• CAS No.: 929297-20-1
• Molecular Formula: C₂₆H₂₅NO₂
• Molecular Weight: 383.49
• Mol file: 929297-20-1.mol

Synonyms:(3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Chemical Property of (3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

There total 1 articles about (3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(3R,11aS)-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one (863908-08-1) + 2-phenethyl iodide (17376-04-4) → (3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one (929297-20-1) + (3R,6S,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Guidance literature:

(3R,11aS)-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1h;

2-phenethyl iodide; In tetrahydrofuran; at 0 ℃; Further stages.;

DOI:10.1002/ejoc.200600746

Reference yield: 91.0%

(3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one (929297-20-1) → (2R)-2-[(1R)-1-phenethyl-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 0 ℃;

DOI:10.1002/ejoc.200600746

Reference yield:

(3R,6R,11aS)-6-phenethyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one (929297-20-1) → (R)-1-phenethyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 0 °C

2: 58 percent / ammonium formate / Pd/C / methanol / Heating

With lithium aluminium tetrahydride; aluminium trichloride; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1002/ejoc.200600746

upstream raw materials:

(3R,11aS)-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

2-phenethyl iodide