N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 1020083-84-4
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.352
• Mol file: 1020083-84-4.mol

Synonyms:N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester

Chemical Property of N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester

There total 2 articles about N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N'-(phenylmethylene)hydrazinecarboxylic acid tert-butyl ester (24469-50-9) + allylmagnesium bromide (1730-25-2) → N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester (1020083-84-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03001

Reference yield: 75.0%

t-butyl 3-benzylidenecarbazate (24469-50-9) + allylmagnesium bromide (1730-25-2) → N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester (1020083-84-4)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 66.0%

N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester (1020083-84-4) + meta-bromotoluene (591-17-3) → tert-butyl (+/-)-(3R,5S)-5-(3-methylbenzyl)-3-phenylpyrazolidine-1-carboxylate + tert-butyl (+/-)-(3R,5R)-5-(3-methylbenzyl)-3-phenylpyrazolidine-1-carboxylate

Guidance literature:

With palladium diacetate; sodium tert-butoxide; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 70 ℃; for 6h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

upstream raw materials:

N'-(phenylmethylene)hydrazinecarboxylic acid tert-butyl ester

allylmagnesium bromide

t-butyl 3-benzylidenecarbazate

Downstream raw materials:

N'-phenylacetyl-N'-(1-phenylbut-3-enyl)hydrazinecarboxylic acid tert-butyl ester

di-tert-butyl (+/-)-1-(1-phenylbut-3-enyl)hydrazine-1,2-dicarboxylate