N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

Base Information

Chemical Name:N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide
CAS No.:1529806-76-5
Molecular Formula:C₄₀H₃₇N₃O₄S₂
Molecular Weight:687.883
Hs Code.:

Synonyms:N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

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Chemical Property of N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

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Technology Process of N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

There total 14 articles about N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584210-03-6
3-(2-methyl-1-tosylaziridin-2-yl)prop-2-yn-1-ol

: 1584224-32-7
C₂₇H₂₄N₂O₂S

: 1529806-76-5
N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; Inert atmosphere;
DOI:10.1016/j.tet.2013.11.084

Reference yield:

: 66-77-3
1-naphthaldehyde

: 1529806-76-5
N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / methanol / 3 h / -10 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / Reflux; Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 1 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

5.1: manganese(IV) oxide / tetrahydrofuran / 4 h / Inert atmosphere

6.1: titanium(IV) tetraethanolate / toluene / 4 h / Reflux

7.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / 0 - 20 °C

8.1: triphenylphosphine; diethylazodicarboxylate / toluene / Inert atmosphere

With manganese(IV) oxide; titanium(IV) tetraethanolate; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium methylate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide; toluene; mineral oil; 8.1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.11.084

Reference yield:

: 55970-06-4
methyl 3H-benz[e]indole-2-carboxylate

: 1529806-76-5
N-((3-benzyl-3H-benzo[e]indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

3.1: manganese(IV) oxide / tetrahydrofuran / 4 h / Inert atmosphere

4.1: titanium(IV) tetraethanolate / toluene / 4 h / Reflux

5.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / 0 - 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene / Inert atmosphere

With manganese(IV) oxide; titanium(IV) tetraethanolate; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil; 6.1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.11.084