1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

Base Information

Chemical Name:1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one
CAS No.:701209-09-8
Molecular Formula:C₃₁H₃₃N₃O₃
Molecular Weight:495.621
Hs Code.:

Synonyms:1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

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Chemical Property of 1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

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Technology Process of 1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

There total 3 articles about 1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2904-57-6
mesitylenecarbonitrile oxide

: 394220-60-1
1-benzyl-2-(3-phenyl-acryloyl)-5,5-dimethyl-pyrazolidin-3-one

: 701209-09-8
1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

Guidance literature:: With 4 A molecular sieve; chiral amino indanol derivative; magnesium iodide; In toluene; at 70 ℃; for 14h;
DOI:10.1021/ja0318636

Reference yield:

: 131391-08-7
1-benzyl-5,5-dimethyl-pyrazolidin-3-one

: 701209-09-8
1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 93 percent / tetrahydrofuran / -78 °C

2.1: 85 percent / MgI₂; chiral amino indanol derivative; 4A molecular sieves / toluene / 14 h / 70 °C

With n-butyllithium; 4 A molecular sieve; chiral amino indanol derivative; magnesium iodide; In tetrahydrofuran; toluene;
DOI:10.1021/ja0318636

Reference yield:

: 42953-82-2
5,5-dimethylpyrazolidin-3-one

: 701209-09-8
1-benzyl-2-[4',5'-trans-dihydro-4-phenyl-3-(2,4,6-trimethylphenyl)isoxazol-5-yl]-5,5-dimethylpyrazolidine-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / K₂CO₃; NaI / butan-2-one / Heating

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

2.2: 93 percent / tetrahydrofuran / -78 °C

3.1: 85 percent / MgI₂; chiral amino indanol derivative; 4A molecular sieves / toluene / 14 h / 70 °C

With n-butyllithium; 4 A molecular sieve; chiral amino indanol derivative; potassium carbonate; sodium iodide; magnesium iodide; In tetrahydrofuran; toluene; butanone;
DOI:10.1021/ja0318636