2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

Base Information

Chemical Name:2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid
CAS No.:1361383-95-0
Molecular Formula:C₃₄H₂₈F₃NO₃S₂
Molecular Weight:619.728
Hs Code.:

Synonyms:2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

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Chemical Property of 2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

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Technology Process of 2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

There total 6 articles about 2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361383-94-9
C₃₆H₃₂F₃NO₃S₂

: 1361383-95-0
2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

Guidance literature:: C₃₆H₃₂F₃NO₃S₂; With sodium hydroxide; In ethanol; for 1h; Inert atmosphere;

With hydrogenchloride; In ethanol; water; pH=3; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.03.055

Reference yield:

: 1361383-92-7
C₃₈H₄₀F₃NOS₂Si

: 1361383-95-0
2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium carbonate / acetone / 6 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / ethanol / 1 h / Inert atmosphere

3.2: pH 3 / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/j.ejmech.2012.03.055

Reference yield:

: 5-[4-(tetr-butyldimethylsilanyloxy)-3-methyl-phenylsulfanyl-methyl]-4-methyl-2-[(4-trifluoromethyl)phenyl]thiazole

: 1361383-95-0
2-(4-(2-(biphenyl-4-yl)-1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)ethylthio)-2-methylphenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium carbonate / acetone / 6 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / ethanol / 1 h / Inert atmosphere

4.2: pH 3 / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium carbonate; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/j.ejmech.2012.03.055