N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

Base Information

Chemical Name:N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester
CAS No.:661464-13-7
Molecular Formula:C₃₂H₃₈N₄O₅
Molecular Weight:558.678
Hs Code.:

Synonyms:N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

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Chemical Property of N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

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Technology Process of N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

There total 5 articles about N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 661464-12-6
N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}phenylalanine ethyl ester

: 661464-13-7
N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1002/ejoc.200300692

Reference yield:

: 14338-36-4
3-amino phenylacetic acid

: 661464-13-7
N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; HCl / H₂O / 0.33 h

1.2: 98 percent / H₂O; acetic acid / 2 h / 20 °C

2.1: 91 percent / DCC; HOBt / dimethylformamide

3.1: 46 percent / DMAP / acetonitrile / 48 h / 20 °C

With hydrogenchloride; dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200300692

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 661464-13-7
N-{3-[(N,N-dimethylaminophenyl)-4'-diazenyl]phenylacetyl}-N-tert-butyloxycarbonylphenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / DCC; HOBt / dimethylformamide

2: 46 percent / DMAP / acetonitrile / 48 h / 20 °C

With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200300692