6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

Base Information

Chemical Name:6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile
CAS No.:119348-70-8
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

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Chemical Property of 6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

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Technology Process of 6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

There total 5 articles about 6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 151-50-8
potassium cyanide

: 135312-32-2
1-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-5-chloro-pentan-1-one

: 119348-70-8
6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 6h;
DOI:10.1021/jm00113a014

Reference yield:

: 1575-61-7
5-Chlorovaleroyl chloride

: 119348-70-8
6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / AlCl₃ / CH₂Cl₂ / 6 h

2: 59 percent / dimethylformamide / 6 h / 60 °C

With aluminium trichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a014

Reference yield:

: 97582-36-0
1-<4-(chloromethyl)-2-hydroxy-3-propylphenyl>ethanone

: 119348-70-8
6-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-6-oxo-hexanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / NaOEt, NaI / ethanol / 72 h

2: 77 percent / AlCl₃ / CH₂Cl₂ / 6 h

3: 59 percent / dimethylformamide / 6 h / 60 °C

With aluminium trichloride; sodium ethanolate; sodium iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a014