2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

Base Information

Chemical Name:2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide
CAS No.:1566543-30-3
Molecular Formula:C₂₀H₂₁F₃N₆O
Molecular Weight:418.422
Hs Code.:

Synonyms:2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

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Chemical Property of 2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

There total 7 articles about 2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1387582-44-6
4-chloro-N-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-amine

: 1566543-62-1
2-(2-ethynylphenyl)propanamide

: 1566543-30-3
2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

Guidance literature:: 4-chloro-N-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-amine; 2-(2-ethynylphenyl)propanamide; With copper(l) iodide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 0.166667h; Sonication;

With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Microwave irradiation;

With palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 615256-95-6
2-iodo-2-phenylacetic acid

: 1566543-30-3
2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / 40 °C

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

4.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h / Sonication

4.2: 0.33 h / 120 °C / Microwave irradiation

4.3: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 33994-46-6
2-(2-iodophenyl)propanoic acid

: 1566543-30-3
2-(2-(2-(2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl) propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

4.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h / Sonication

4.2: 0.33 h / 120 °C / Microwave irradiation

4.3: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In tetrahydrofuran; N,N-dimethyl-formamide;