trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide

Base Information

Chemical Name:trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide
CAS No.:77302-19-3
Molecular Formula:C₁₂H₁₂F₃NO
Molecular Weight:243.229
Hs Code.:
Wikidata:Q76149510
ChEMBL ID:CHEMBL151463

Synonyms:trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide;CINNAMAMIDE, alpha,beta-DIMETHYL-m-TRIFLUOROMETHYL-, (E)-;77302-19-3;CHEMBL151463;LS-53947

Suppliers and Price of trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide

Chemical Property:

Vapor Pressure:7.06E-05mmHg at 25°C
Boiling Point:343.4°Cat760mmHg
Flash Point:161.5°C
Density:1.21g/cm³
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:243.08709849
Heavy Atom Count:17
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=C(C)C(=O)N)C1=CC(=CC=C1)C(F)(F)F
Isomeric SMILES:C/C(=C(/C)\C(=O)N)/C1=CC(=CC=C1)C(F)(F)F

Technology Process of trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide

There total 3 articles about trans-alpha,beta-Dimethyl-m-trifluoromethylcinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 344557-44-4
(E)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoyl chloride

: 77302-19-3
(E)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid amide

Guidance literature:: With ammonia; In benzene; for 12h; Yield given;
DOI:10.1021/jm00137a010

Reference yield:

: 77302-35-3
(E)-m-(trifluoromethyl)-α,β-dimethylcinnamic acid

: 77302-19-3
(E)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, CaCO₃ / benzene; dimethylformamide / 24 h / Ambient temperature

2: NH₃(gas) / benzene / 12 h

With oxalyl dichloride; ammonia; calcium carbonate; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00137a010

Reference yield:

: 52094-29-8,52094-30-1
(Z)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid ethyl ester

: 77302-19-3
(E)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / dioxane; H₂O / 8 h / Heating

2: oxalyl chloride, CaCO₃ / benzene; dimethylformamide / 24 h / Ambient temperature

3: NH₃(gas) / benzene / 12 h

With potassium hydroxide; oxalyl dichloride; ammonia; calcium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00137a010