9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

Base Information

Chemical Name:9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine
CAS No.:262863-49-0
Molecular Formula:C₄₀H₄₃ClN₆O₉P₂
Molecular Weight:849.217
Hs Code.:

Synonyms:9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

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Chemical Property of 9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

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Technology Process of 9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

There total 5 articles about 9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 262863-48-9
2-chloro-9-[(diethanolamino)carboxymethyl]-6-methylamino-purine

: 262863-49-0
9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

Guidance literature:: 2-chloro-9-[(diethanolamino)carboxymethyl]-6-methylamino-purine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; In tetrahydrofuran; at 0 - 25 ℃; for 12h; Further stages.;
DOI:10.1021/jm9905211

Reference yield:

: 82499-02-3
2-chloro-6-(N-methylamino)-9H-purine

: 262863-49-0
9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 25 °C

1.2: 82 percent / dimethylformamide / 12 h / 25 °C

2.1: 83 percent / 1 N aq. NaOH / 1 h / 25 °C

3.1: EDAC; DMAP / CH₂Cl₂; dimethylformamide / 2 h / 25 °C

4.1: 36 percent / methanol / 12 h / 25 °C

5.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

5.2: 94 percent / tetrahydrofuran / 12 h / 0 - 25 °C

With dmap; sodium hydroxide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: deprotonation / 1.2: Condensation / 2.1: Hydrolysis / 3.1: Esterification / 4.1: Substitution / 5.1: deprotonation / 5.2: phosphorylation;
DOI:10.1021/jm9905211

Reference yield:

: 262863-47-8
(2-chloro-6-methylamino-purin-9-yl)-acetic acid

: 262863-49-0
9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: EDAC; DMAP / CH₂Cl₂; dimethylformamide / 2 h / 25 °C

2.1: 36 percent / methanol / 12 h / 25 °C

3.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

3.2: 94 percent / tetrahydrofuran / 12 h / 0 - 25 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: Substitution / 3.1: deprotonation / 3.2: phosphorylation;
DOI:10.1021/jm9905211