(S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

Base Information

Chemical Name:(S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide
CAS No.:146236-47-7
Molecular Formula:C₃₀H₃₁NO₁₀
Molecular Weight:565.577
Hs Code.:

Synonyms:(S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

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Chemical Property of (S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

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Technology Process of (S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

There total 4 articles about (S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 143616-19-7
(S)-dihydro-4-(3,4,5-trimethoxybenzyl)furan-2(3H)-one

: 146120-79-8
3,5-dimethoxy-4-(4-nitrobenzyloxy)-benzaldehyde

: 146236-47-7
(S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

Guidance literature:: With 2-(Dimethylamino)pyridine; n-butyllithium; diaza-bicyclo-undecene; acetic anhydride; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 133269-68-8
(S)-3-methoxycarbonyl-4-(3,4,5-trimethoxy-phenyl)butanoic acid

: 146236-47-7
(S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

Guidance literature:: Multi-step reaction with 2 steps

1: 201 g / KOH, CaCl₂, NaBH₄ / ethanol / 12 h / 0 °C

With potassium hydroxide; sodium tetrahydroborate; calcium chloride; In ethanol;
DOI:10.1016/0040-4020(95)00702-A

Reference yield:

: 165673-39-2
(E)-3-(methoxycarbonyl)-4-(3,4,5-trimethoxy-phenyl)but-3-enoic acid

: 146236-47-7
(S)-(E)-2-<3,5-dimethoxy-4-(4-nitrobenzyloxy)benzylidene>-3-(3,4,5-trimethoxybenzyl)butanolide

Guidance literature:: Multi-step reaction with 3 steps

1: 250 g / Rh(COD)2BF₄, (R,R)-MOD-DIOP, Et₃N, hydrogen / methanol / 42 h / Ambient temperature

2: 201 g / KOH, CaCl₂, NaBH₄ / ethanol / 12 h / 0 °C

With potassium hydroxide; sodium tetrahydroborate; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; hydrogen; (4R-trans)-<(2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)>bis; triethylamine; calcium chloride; In methanol; ethanol;
DOI:10.1016/0040-4020(95)00702-A