(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

Base Information

Chemical Name:(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal
CAS No.:503818-16-4
Molecular Formula:C₂₄H₄₀O₄Si
Molecular Weight:420.665
Hs Code.:

Synonyms:(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

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Chemical Property of (4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

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Technology Process of (4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

There total 5 articles about (4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 503818-23-3
(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-1,1-diisopropoxy-2,2,4,6-tetramethyl-heptan-3-one

: 503818-16-4
(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

Guidance literature:: With water; toluene-4-sulfonic acid; In tetrahydrofuran; at 64 ℃; for 6.5h;
DOI:10.1021/ja029695p

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 503818-16-4
(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 2,6-lutidine / CH₂Cl₂ / -40 - -20 °C

2: 98 percent / p-TsOH*H₂O; H₂O / tetrahydrofuran / 6.5 h / 64 °C

With 2,6-dimethylpyridine; water; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja029695p

Reference yield:

: 79027-28-4
(2S)-3-(benzyloxy)-2-methylpropanal

: 503818-16-4
(4R,5S,6S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-3-oxo-heptanal

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / 0.58 h / -90 °C

2: 97 percent / 2,6-lutidine / CH₂Cl₂ / -40 - -20 °C

3: 98 percent / p-TsOH*H₂O; H₂O / tetrahydrofuran / 6.5 h / 64 °C

With 2,6-dimethylpyridine; water; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja029695p