methotrexate alpha-aspartate

Base Information

Chemical Name:methotrexate alpha-aspartate
CAS No.:71074-48-1
Molecular Formula:C24H27 N9 O8
Molecular Weight:569.53
Hs Code.:

Synonyms:L-Asparticacid, N-[N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-a-glutamyl]-; GW 3347; NSC 292225

Suppliers and Price of methotrexate alpha-aspartate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of methotrexate alpha-aspartate

Chemical Property:

PSA：276.94000
Density:1.57g/cm³
LogP:1.17210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methotrexate alpha-aspartate

There total 8 articles about methotrexate alpha-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 71074-48-1
(S)-2-((S)-4-Carboxy-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-succinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / (i-Pr)2NEt / dioxane; H₂O

2: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

3: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

4: H₂ / 5percent Pd/C / dioxane / 20 h / Ambient temperature

5: N,N-dimethyl-acetamide / 120 h / 25 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00344a018

Reference yield:

: 10541-83-0,937737-33-2
N-methyl-p-aminobenzoic acid

: 71074-48-1
(S)-2-((S)-4-Carboxy-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-succinic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / 2 N NaOH / dioxane; H₂O / 0.5 h / 0 - 5 °C

2: 99 percent / SOCl₂ / benzene / 2 h / Heating

3: 68 percent / (i-Pr)2NEt / dioxane; H₂O

4: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

5: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

6: H₂ / 5percent Pd/C / dioxane / 20 h / Ambient temperature

7: N,N-dimethyl-acetamide / 120 h / 25 °C

With sodium hydroxide; thionyl chloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00344a018

Reference yield:

: 2528-30-5
4-<<(benzyloxy)carbonyl>methylamino>benzoic acid

: 71074-48-1
(S)-2-((S)-4-Carboxy-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-succinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / SOCl₂ / benzene / 2 h / Heating

2: 68 percent / (i-Pr)2NEt / dioxane; H₂O

3: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

4: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

5: H₂ / 5percent Pd/C / dioxane / 20 h / Ambient temperature

6: N,N-dimethyl-acetamide / 120 h / 25 °C

With thionyl chloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00344a018