N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

Base Information

Chemical Name:N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide
CAS No.:1313036-67-7
Molecular Formula:C₃₃H₄₁ClFN₇O₄Si
Molecular Weight:682.27
Hs Code.:

N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

Synonyms:N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

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Chemical Property of N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

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Technology Process of N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

There total 9 articles about N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1313036-66-6
4-(3-amino-5-fluorophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1313036-67-7
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

Guidance literature:: 4-(3-amino-5-fluorophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

acryloyl chloride; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1313036-67-7
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: potassium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 14 h / 90 °C

4.1: ethanol; tin(ll) chloride / 0.5 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C

5.2: 1 h / 0 °C

With ethanol; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: Buckwald's amination;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1313036-67-7
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-5-fluorophenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: potassium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 14 h / 90 °C

4.1: ethanol; tin(ll) chloride / 0.5 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C

5.2: 1 h / 0 °C

With ethanol; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: Buckwald's amination;