3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

Base Information

Chemical Name:3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester
CAS No.:478541-69-4
Molecular Formula:C₃₆H₄₂N₂O₆
Molecular Weight:598.739
Hs Code.:

3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid <i>tert</i>-butyl ester

Synonyms:3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

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Chemical Property of 3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

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Technology Process of 3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

There total 9 articles about 3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 478541-45-6
3-[4-hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

: 328918-86-1
toluene-4-sulfonic acid 2-(2-biphenyl-4-yl-5-methyloxazol-4-yl)ethyl ester

: 478541-69-4
3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.09.011

Reference yield:

: 3-(2-formyl-4-hydroxy-phenyl)-acrylic acid tert-butyl ester

: 478541-69-4
3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / NH₂OH*HCl; pyridine / ethanol

2: 87 percent / H₂ / Pd/C / ethanol / 2585.74 Torr

3: 94 percent / TEA / CH₂Cl₂

4: 100 percent / Cs₂CO₃ / dimethylformamide

With pyridine; TEA; hydroxylamine hydrochloride; hydrogen; caesium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.09.011

Reference yield:

: 3-[4-hydroxy-2-(hydroxyimino-methyl)-phenyl]-acrylic acid tert-butyl ester

: 478541-69-4
3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / H₂ / Pd/C / ethanol / 2585.74 Torr

2: 94 percent / TEA / CH₂Cl₂

3: 100 percent / Cs₂CO₃ / dimethylformamide

With TEA; hydrogen; caesium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.09.011