2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

Base Information

Chemical Name:2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid
CAS No.:1080521-20-5
Molecular Formula:C₂₂H₁₇Cl₂N₃O₆S
Molecular Weight:522.365
Hs Code.:

Synonyms:2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

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Chemical Property of 2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

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Technology Process of 2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

There total 9 articles about 2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080522-62-8
methyl 2-(4-(4-(2,4-dichlorophenylsulfonamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetate

: 1080521-20-5
2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: methyl 2-(4-(4-(2,4-dichlorophenylsulfonamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetate; With hydrogenchloride; water; In ethanol; for 3h; Heating / reflux;

With lithium hydroxide; water; In tetrahydrofuran; for 1h; Heating / reflux;

Reference yield:

: 1080522-54-8
5-chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole

: 1080521-20-5
2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C

1.2: 120 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / 0.75 h

3.1: pyridine / dichloromethane / 20 °C

4.1: hydrogenchloride; water / ethanol / 3 h / Heating / reflux

4.2: 1 h / Heating / reflux

With pyridine; hydrogenchloride; water; hydrogen; sodium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 606-20-2
2,6-dinitrotoluene

: 1080521-20-5
2-(4-(4-(2,4-dichlorophenylsulfonamido)-1H-indazol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide; hydroxylamine hydrochloride / methanol; ethanol / 20 °C

1.2: 1 h

2.1: tert.-butylnitrite; copper(l) chloride / acetonitrile / 0.25 h / 60 - 65 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; cyclohexene / 2 h / Heating / reflux

4.1: sodium nitrite / water; acetic acid / 4 h / 20 °C / Heating / reflux

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C

6.2: 120 h / Heating / reflux

7.1: hydrogen / palladium 10% on activated carbon / 0.75 h

8.1: pyridine / dichloromethane / 20 °C

9.1: hydrogenchloride; water / ethanol / 3 h / Heating / reflux

9.2: 1 h / Heating / reflux

With pyridine; hydrogenchloride; potassium hydroxide; tert.-butylnitrite; hydroxylamine hydrochloride; water; hydrogen; sodium hexamethyldisilazane; sodium hydride; copper(l) chloride; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; cyclohexene;