N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Base Information

Chemical Name:N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide
CAS No.:83562-06-5
Molecular Formula:C₁₉H₁₄ClN₃OS
Molecular Weight:367.859
Hs Code.:

Synonyms:N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Suppliers and Price of N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

There total 8 articles about N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 83562-05-4
N-<4-(2-benzoyl-4-chlorophenyl)-5-cyanothiazol-2-yl>acetamide

: 83562-06-5
N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Guidance literature:: With hydrogen; nickel; In ethanol; for 2h; under 930.9 Torr;
DOI:10.1021/jm00355a020

Reference yield:

: 21143-53-3
methyl 2-benzyl-4-chlorobenzoate

: 83562-06-5
N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / NaNH₂ / liquid ammonia; diethyl ether / 1 h

2: CuBr₂, 1,2-epoxy-3-phenoxypropane / tetrahydrofuran; ethyl acetate; CHCl₃ / 5 h / Heating

3: 43 percent / ethanol / 2 h / Heating

4: 100 percent / 0.75 h / Heating

5: 27 percent / sodium dichromate, acetic acid / 15 h / Heating

6: 37 percent / H₂ / Raney nickel / ethanol / 2 h / 930.9 Torr

With sodium dichromate; Phenyl glycidyl ether; hydrogen; sodium amide; acetic acid; copper(ll) bromide; nickel; In tetrahydrofuran; diethyl ether; ethanol; chloroform; ammonia; ethyl acetate;
DOI:10.1021/jm00355a020

Reference yield:

: 21143-54-4
2-Benzyl-4-chlorobenzyl alcohol

: 83562-06-5
N-(8-chloro-6-phenyl-4H-thiazolo<5,4-d><2>benzazepin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

2: 87 percent / NaCN, MnO₂ / 6 h / Ambient temperature

3: 77 percent / NaNH₂ / liquid ammonia; diethyl ether / 1 h

4: CuBr₂, 1,2-epoxy-3-phenoxypropane / tetrahydrofuran; ethyl acetate; CHCl₃ / 5 h / Heating

5: 43 percent / ethanol / 2 h / Heating

6: 100 percent / 0.75 h / Heating

7: 27 percent / sodium dichromate, acetic acid / 15 h / Heating

8: 37 percent / H₂ / Raney nickel / ethanol / 2 h / 930.9 Torr

With manganese(IV) oxide; sodium dichromate; Phenyl glycidyl ether; sodium cyanide; hydrogen; sodium amide; acetic acid; pyridinium chlorochromate; copper(ll) bromide; nickel; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; ammonia; ethyl acetate;
DOI:10.1021/jm00355a020