2-[2-(2-Oxoindol-3-yl)hydrazinyl]-1,3-thiazol-4-one

Base Information

• Chemical Name: 2-[2-(2-Oxoindol-3-yl)hydrazinyl]-1,3-thiazol-4-one
• CAS No.: 22915-25-9
• Molecular Formula: C11H8N4O2S
• Molecular Weight: 260.2718
• NSC Number: 134357
• DSSTox Substance ID: DTXSID70415309
• ChEMBL ID: CHEMBL1761730
• Mol file: 22915-25-9.mol

Synonyms:22915-25-9;2-[2-(2-oxoindol-3-yl)hydrazinyl]-1,3-thiazol-4-one;CHEMBL1761730;2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-1,3-thiazol-4-one;1H-Indole-2,3-dione, 3-[2-(4,5-dihydro-4-oxo-2-thiazolyl)hydrazone];(3Z)-3-[(2Z)-(4-oxo-1,3-thiazolidin-2-ylidene)hydrazinylidene]-1,3-dihydro-2H-indol-2-one;NSC134357;SCHEMBL23483886;DTXSID70415309;HMS1608H11;STK020442;AKOS000609163;AKOS005378871;NSC-134357;AG-690/33357030;BRD-K09441612-001-01-0;2-(2-(2-Oxo-2H-indol-3-yl)hydrazinyl)thiazol-4(5H)-one;1H-indole-2,3-dione 3-[(4-oxo-1,3-thiazolidin-2-ylidene)hydrazone];1H-indole-2,3-dione 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)hydrazone];(3Z)-1H-indole-2,3-dione 3-{[(2E)-4-oxo-1,3-thiazolidin-2-ylidene]hydrazone};(3E)-3-{2-[(2Z)-4-OXO-1,3-THIAZOLIDIN-2-YLIDENE]HYDRAZIN-1-YLIDENE}-2,3-DIHYDRO-1H-INDOL-2-ONE

Chemical Property of 2-[2-(2-Oxoindol-3-yl)hydrazinyl]-1,3-thiazol-4-one

Chemical Property:

• Vapor Pressure: 2.03E-09mmHg at 25°C
• Boiling Point: 481.2°C at 760 mmHg
• Flash Point: 244.8°C
• Density: 1.71g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 260.03679668
• Heavy Atom Count: 18
• Complexity: 412

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)N=C(S1)N=NC2=C(NC3=CC=CC=C32)O

Technology Process of 2-[2-(2-Oxoindol-3-yl)hydrazinyl]-1,3-thiazol-4-one

There total 5 articles about 2-[2-(2-Oxoindol-3-yl)hydrazinyl]-1,3-thiazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

indole-2,3-dione 3-thiosemicarbazone (1165809-20-0) + chloroacetic acid (79-11-8) → 3-[(1,3-thiazolidin-4-one-2-yl)hydrazido]-indole-2-one (22915-25-9)

Guidance literature:

With sodium acetate; In ethanol; for 0.15h; Microwave irradiation;

DOI:10.1080/10426500903567554

Reference yield: 75.0%

indole-2,3-dione 3-thiosemicarbazone (1165809-20-0) + chloroacetic acid (79-11-8) → 2-(Isatin-3-azino)-4-thiazolidinone (22915-25-9)

Guidance literature:

With sodium acetate; In ethanol; for 30h; Heating;

Reference yield: 66.0%

(Z)-2-(2-oxoindolin-3-ylidene)-hydrazinecarbothioamide (487-16-1,26134-45-2,27830-79-1,1165809-20-0) + chloroacetic acid (79-11-8) → 1(H)-3-hydrazono-4'-oxo-3'(H)thiazolyl-indolin-2-one (22915-25-9)

Guidance literature:

With sodium acetate; In ethanol; Heating;

DOI:10.1002/jccs.200100134

upstream raw materials:

(Z)-2-(2-oxoindolin-3-ylidene)-hydrazinecarbothioamide

chloroacetic acid

indole-2,3-dione 3-thiosemicarbazone

ethyl bromoacetate

Downstream raw materials:

3-{[5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-4-oxo-thiazolidin-(2E)-ylidene]-hydrazono}-1,3-dihydro-indol-2-one

3-{[5-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-4-oxo-thiazolidin-(2E)-ylidene]-hydrazono}-1,3-dihydro-indol-2-one

3-{[4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-(2E)-ylidene]-hydrazono}-1,3-dihydro-indol-2-one

3-{[5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-thiazolidin-(2E)-ylidene]-hydrazono}-1,3-dihydro-indol-2-one