3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate

Base Information

• Chemical Name: 3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate
• CAS No.: 1156490-47-9
• Molecular Formula: C₂₅H₃₃NO₄S
• Molecular Weight: 443.607
• Mol file: 1156490-47-9.mol

Synonyms:3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate

Chemical Property of 3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate

There total 2 articles about 3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(Z)-2-phenyl-1-tosylvinyl N,N-diisopropylcarbamate (1156490-34-4) + isopropenylmagnesium bromide (13291-18-4) → 3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate (1156490-47-9)

Guidance literature:

isopropenylmagnesium bromide; With copper(II) bis(trifluoromethanesulfonate); In diethyl ether; at -40 ℃; for 0.166667h;

(Z)-2-phenyl-1-tosylvinyl N,N-diisopropylcarbamate; In diethyl ether; toluene; at -45 ℃; for 16h;

With formic acid; ammonium chloride; In diethyl ether; water; toluene; at -45 ℃;

DOI:10.1021/jo900347s

Reference yield: 84.0%

(E)-2-phenyl-1-tosylvinyl N,N-diisopropylcarbamate (1156490-32-2) + isopropenylmagnesium bromide (13291-18-4) → 3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate (1156490-47-9)

Guidance literature:

isopropenylmagnesium bromide; With copper(II) bis(trifluoromethanesulfonate); In diethyl ether; at -40 ℃; for 0.166667h;

(E)-2-phenyl-1-tosylvinyl N,N-diisopropylcarbamate; In diethyl ether; toluene; at -45 ℃; for 16h;

With formic acid; ammonium chloride; In diethyl ether; water; toluene; at -45 ℃;

DOI:10.1021/jo900347s

Reference yield: 73.0%

3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate (1156490-47-9) → 3-methyl-2-phenylbut-3-en-1-ol (57502-36-0)

Guidance literature:

3-methyl-2-phenyl-1-tosyl-but-3-enyl N,N-diisopropylcarbamate; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 80 ℃; for 8h;

With water; Rochelle's salt; In tetrahydrofuran; hexane; for 0.5h;

DOI:10.1021/jo900347s

upstream raw materials:

(E)-2-phenyl-1-tosylvinyl N,N-diisopropylcarbamate

isopropenylmagnesium bromide

(Z)-2-phenyl-1-tosylvinyl N,N-diisopropylcarbamate

Downstream raw materials:

3-methyl-2-phenylbut-3-en-1-ol