2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

Base Information

Chemical Name:2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester
CAS No.:145220-98-0
Molecular Formula:C₃₈H₃₃N₃O₇
Molecular Weight:643.696
Hs Code.:

Synonyms:2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

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Chemical Property of 2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

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Technology Process of 2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

There total 9 articles about 2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60705-25-1
4,4-dimethoxy-3-oxo-butyric acid methyl ester

: 145220-98-0
2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

Guidance literature:: Multi-step reaction with 8 steps

1: morpholine, AcOH

2: 100 percent / 3 h / 70 - 120 °C

3: 67 percent / 6 N HCl / acetone / 6 h / Ambient temperature

4: NH₂OH*HCl, NaOAc / acetic acid / 1 h / Ambient temperature

5: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 97-105 deg C, 4.5 h

6: 87.1 percent / 98percent HCO₂H / 5 h / Ambient temperature

7: PCl₅ / CHCl₃ / 1.5 h

8: pyridine / CHCl₃ / 2.5 h

With morpholine; pyridine; hydrogenchloride; formic acid; phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; acetic acid; In chloroform; acetic acid; acetone;
DOI:10.1248/cpb.40.1799

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 145220-98-0
2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

Guidance literature:: Multi-step reaction with 8 steps

1: morpholine, AcOH

2: 100 percent / 3 h / 70 - 120 °C

3: 67 percent / 6 N HCl / acetone / 6 h / Ambient temperature

4: NH₂OH*HCl, NaOAc / acetic acid / 1 h / Ambient temperature

5: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 97-105 deg C, 4.5 h

6: 87.1 percent / 98percent HCO₂H / 5 h / Ambient temperature

7: PCl₅ / CHCl₃ / 1.5 h

8: pyridine / CHCl₃ / 2.5 h

With morpholine; pyridine; hydrogenchloride; formic acid; phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; acetic acid; In chloroform; acetic acid; acetone;
DOI:10.1248/cpb.40.1799

Reference yield:

: 67448-15-1
(E,Z)-methyl 4,4-dimethoxy-2-(3-nitrobenzylidene)acetoacetate

: 145220-98-0
2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(1-methyl-2-trityloxy-ethyl) ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / 3 h / 70 - 120 °C

2: 67 percent / 6 N HCl / acetone / 6 h / Ambient temperature

3: NH₂OH*HCl, NaOAc / acetic acid / 1 h / Ambient temperature

4: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 97-105 deg C, 4.5 h

5: 87.1 percent / 98percent HCO₂H / 5 h / Ambient temperature

6: PCl₅ / CHCl₃ / 1.5 h

7: pyridine / CHCl₃ / 2.5 h

With pyridine; hydrogenchloride; formic acid; phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; In chloroform; acetic acid; acetone;
DOI:10.1248/cpb.40.1799