N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide

Base Information

• Chemical Name: N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide
• CAS No.: 1026457-04-4
• Molecular Formula: C₂₀H₂₃NO₇
• Molecular Weight: 389.405
• Mol file: 1026457-04-4.mol

Synonyms:N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide

Chemical Property of N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide

There total 2 articles about N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-dimethoxybenzoic acid chloride (3535-37-3) + 3,5-dimethoxy-2-(methoxyacetyl)aniline (212512-28-2) → N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide (1026457-04-4)

Guidance literature:

With pyridine; for 18h; Heating;

DOI:10.1016/S0223-5234(99)80087-7

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide (1026457-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: BCl₃ / benzene; CH₂Cl₂ / 0.75 h / 0 °C

1.2: TiCl₄ / benzene; CH₂Cl₂ / 22 h / Heating

1.3: 57 percent / aq. HCl / benzene; CH₂Cl₂ / 1 h / Heating

2.1: 95 percent / pyridine / 18 h / Heating

With pyridine; boron trichloride; In dichloromethane; benzene; 1.1: Complexation / 1.2: Substitution / 1.3: Hydrolysis / 2.1: Acylation;

DOI:10.1016/S0223-5234(99)80087-7

Reference yield: 78.0%

N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide (1026457-04-4) → 3,5,7-trimethoxy-2-(3,4-dimethoxyphenyl)-4-oxo-1,4-dihydroquinoline

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 80 ℃; Sealed tube;

DOI:10.1016/j.ejmech.2020.112754

upstream raw materials:

3,4-dimethoxybenzoic acid chloride

3,5-dimethoxy-2-(methoxyacetyl)aniline

3.5-dimethoxyaniline