Technology Process of (-)-(1S,6R)-6-((R)-1-hydroxypropan-2-yl)-3-methylcyclohex-2-enol
There total 3 articles about (-)-(1S,6R)-6-((R)-1-hydroxypropan-2-yl)-3-methylcyclohex-2-enol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3R,3aR,7aS)-3,6-dimethyl-3,3a,4,5-tetrahydrobenzofuran-2(7aH)-one;
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 ℃;
Inert atmosphere;
With
sodium hydroxide;
In
diethyl ether; water;
at 0 - 23 ℃;
DOI:10.1021/jo902029x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2.1: diphenyl diselenide; sodium tetrahydroborate / methanol / 3 h / 20 - 65 °C / Inert atmosphere
2.2: 12 h / 0 - 65 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere
With
sodium tetrahydroborate; disodium hydrogenphosphate; lithium aluminium tetrahydride; diphenyl diselenide; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol302106y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diphenyl diselenide; sodium tetrahydroborate / methanol / 3 h / 20 - 65 °C / Inert atmosphere
1.2: 12 h / 0 - 65 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere
With
sodium tetrahydroborate; lithium aluminium tetrahydride; diphenyl diselenide;
In
tetrahydrofuran; methanol;
DOI:10.1021/ol302106y
