(+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Base Information

• Chemical Name: (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate
• CAS No.: 1191300-99-8
• Molecular Formula: C₂₂H₂₁ClN₂O₃
• Molecular Weight: 396.873
• Mol file: 1191300-99-8.mol

Synonyms:(+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Chemical Property of (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate

There total 3 articles about (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C22H21ClN2O3 (1191301-00-4) → (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate (1191300-99-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetone; for 4h; Reflux;

DOI:10.1021/op9001824

Reference yield: 72.0%

(4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester (252349-31-8) → (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate (1191300-99-8)

Guidance literature:

With triethylamine; triphenylphosphine; palladium dichloride; In toluene; Heating; Large scale reaction;

DOI:10.1021/op9001824

Reference yield:

→ (+/-)-Ethyl 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylate (1191300-99-8)

Guidance literature:

upstream raw materials:

(4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

C₂₂H₂₁ClN₂O₃

Downstream raw materials:

C₂₂H₂₁ClN₂O₃